SCALED-UP PREPARATION OF DRUG-LOADED ELECTROSPUN POLYMER FIBRES AND INVESTIGATION OF THEIR CONTINUOUS PROCESSING TO TABLET FORM

Polymer-based electrospun amorphous solid dispersions (ASDs) were prepared and investigated from pharmaceutical application point of view.Spironolactone (SPIR) was used as model drug mixed in various concentrations with polymers suitable for fibre formation, such as vinylpyrrolidone-vinyl acetate copolymer, polyvinylpyrrolidone K30 and hydroxypropy

O presente estudo foi delineado para avaliar os efeitos imediatos e tardios da restrição protéica durante a vida fetale neonatal sobre a ação periférica da insulina em ratos.Ratas grávidas da linhagem Wistar foram alimentadas,durante a gravidez e a lactação, com dietas isocalóricas hipoprotéica (6% de proteína) e normoprotéica (17% dep